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MilliporeSigma Launches Gene Editing Technology

Designed to engineer virus resistant CHO cell lines

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By: Tim Wright

Editor-in-Chief, Contract Pharma

MilliporeSigma has launched a gene editing technology to modify CHO cell lines to be resistant to minute virus of mice (MVM), a common contamination threat that remains despite the shift to chemically-defined, animal component-free manufacturing processes. CHO cells are commonly used in the manufacture of biologics. MilliporeSigma’s new Centinel technology targets genes, which play a role in MVM susceptibility. Viral contaminations like MVM can have major consequences for biopharmaceuti...

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